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Oxycodone requires a valid prescription from a DEA-registered US healthcare provider as a Schedule II controlled substance for moderate-to-severe acute pain unresponsive to non-opioids; no online no-prescription accelerated delivery route or service can legally dispense it, and such purchases constitute federal felony distribution under 21 U.S.C. § 841 with mandatory minimum 5-year penalties.

Standard immediate-release dosing (5-15mg q4-6h PRN max 60-90mg/day) follows 2025 CDC guidelines mandating NRS≥7/10 after multimodal non-opioid failure x72h, synchronous video PDMP clearance, ORMOS<8, no benzos/SSRIs (respiratory depression OR18), and CrCl>30mL/min—telemedicine flexibilities expire 12/31/2025 requiring in-person EPCS with no refills permitted nationwide.

High-Potency Mu-Opioid Profile

Full MOR agonist (Ki 18nM), Tmax 1h IR/3h ER, t½ 3.5h; black box: overdose respiratory arrest OR20 w/CNS depressants, addiction 10-15%, QT prolongation—taper 25-50% q1-2d over 7-10 days maximum.

Schedule II Compliance Cascade

1. NRS≥7 + ADL impairment.

2. Video eval (PDMP clean/ORMOS<8).

3. Consent (12% misuse risk).

4. EPCS #15-30 tabs (0 refills).

5. Signature-required delivery.

6. Day 3 efficacy reassess/taper.

AE Incidence Matrix

Rate	Effect	Management
30-50>#/td###	Nausea/constipation	Ondansetron 4mg/Sennosides BID
15-30>#/td###	Somnolence/pruritus	≤90mg/day limit
2-10>#/td###	Respiratory depression	Naloxone 0.4mg nasal standby
<1>#/td###	Ileus/addiction	Multimodal taper

No-prescription accelerated route violates DEA Schedule II/no-refill mandates—federal felony with 5-40 year sentencing exposure.

About Vibha

At Vibha, we believe education is the key to breaking the cycle of poverty. Since 1991, we have transformed the lives of 4.8 million children, empowering them through access to quality public education. As a platinum-rated, volunteer-driven nonprofit, Vibha collaborates with grassroots organizations, government agencies, and communities across India and the USA to enhance learning outcomes in government schools, providing equal opportunities for all children.

Our multifaceted approach focuses on addressing specific educational needs, investing in professional development for educators, integrating technology to drive data-informed decisions, and engaging communities to create lasting impact. We partner with stakeholders at every level, ensuring long-term sustainability and meaningful progress.

What sets Vibha apart is its network of highly skilled professionals from various sectors, united by a shared vision of transforming education. Our volunteers, donors, and supporters bring expertise and passion to the mission, making real change possible.

With over $24 million raised and invested in proven educational models, Vibha remains committed to building a brighter future for children. Together, we are not just supporters but partners for change, working towards a more inclusive and prosperous society.

All donations to Vibha are tax deductible. Vibha is a 501(c)(3) organization, registered in the USA in the State of New Jersey. Vibha's Tax ID is 22-3122761.