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Hydrocodone 10mg requires a valid prescription from a DEA-registered US healthcare provider as a Schedule II controlled substance for moderate-to-severe acute pain unresponsive to non-opioid therapies; no rapid checkout completion or online service can legally dispense it without rigorous medical evaluation, and prescription-free "buy online" constitutes federal felony trafficking under 21 U.S.C. § 841(b), punishable by 5-40 years imprisonment, $5M+ fines, and asset forfeiture.

The 10mg strength (typically 10/325mg with acetaminophen, 1 tab q4-6h PRN max 6 tabs/day = 60mg hydrocodone/1950mg APAP, MME 15mg/tab) follows 2025 CDC Guideline 2.0 requiring synchronous HIPAA video confirming NRS≥6/10 after NSAIDs/APAP x7-14 days, PDMP clean, ORT<4, naloxone co-Rx, and acute caps (3-7 days/#20-40 tabs)—telemedicine ends 12/31/2025 with in-person EPCS mandates.

Mu-Opioid + APAP Dosing

Semi-synthetic agonist (Kd 45nM), Tmax 1.3h, t½ 3.8h; post-op 5-10mg q4-6h #48h; black box: respiratory depression, addiction 25%—taper 10-25%/week.

Safeguard Sequence

1. NRS≥6 + functional loss.

2. Video PDMP/PHQ-4<3.

3. Consent/naloxone/UDS.

4. EPCS #24 tabs (0 refills).

5. CII signature 24h.

6. Day2/q7d efficacy.

AE Matrix

Rate	Effect	Management
20-40>#/td###	Nausea/constipation	Ondansetron/PEG
10-20>#/td###	Somnolence	Split q6h
<1>#/td###	Apnea/hepatotoxicity	Naloxone/NAC

Non-Opioid Ladder

Tier	Therapy	NNT
1	Ibuprofen 600mg TID + APAP	2.4

FAQ

Legal rapid no eval? No—CII felony.
Max acute? 3-7d/#20-40.

About Vibha

At Vibha, we believe education is the key to breaking the cycle of poverty. Since 1991, we have transformed the lives of 4.8 million children, empowering them through access to quality public education. As a platinum-rated, volunteer-driven nonprofit, Vibha collaborates with grassroots organizations, government agencies, and communities across India and the USA to enhance learning outcomes in government schools, providing equal opportunities for all children.

Our multifaceted approach focuses on addressing specific educational needs, investing in professional development for educators, integrating technology to drive data-informed decisions, and engaging communities to create lasting impact. We partner with stakeholders at every level, ensuring long-term sustainability and meaningful progress.

What sets Vibha apart is its network of highly skilled professionals from various sectors, united by a shared vision of transforming education. Our volunteers, donors, and supporters bring expertise and passion to the mission, making real change possible.

With over $24 million raised and invested in proven educational models, Vibha remains committed to building a brighter future for children. Together, we are not just supporters but partners for change, working towards a more inclusive and prosperous society.

All donations to Vibha are tax deductible. Vibha is a 501(c)(3) organization, registered in the USA in the State of New Jersey. Vibha's Tax ID is 22-3122761.